Abtract Cerebral ischemia-reperfusion injury is a progressive disease that results in the lack of oxygen and nutrients needed for cellular metabolism in neurons due to blood flow disorders. The pathogenesis of this disease is different; however, it has been shown that the onset of inflammation interacts with I/R through the production of active oxygen species and increases the apoptosis of the neural cells. Therefore, different signaling pathways interfere with the induction of inflammation and the production of active oxygen species. Therefore, the common point of these pathways leads to the appearance of apotosisinducing molecules and inhibit the expression of anti-apoptosis molecules such as BCL-2. In the other hand, due to the dual role of some of these pathways in apoptosis and angiogenesis, it can be said that further studies can be useful in finding suitable therapeutic strategies based on the pathogenesis of Cerebral ischemia-reperfusion injury inducing angiogenesis in order to repair damaged veins and prevent disease progression. Keywords: Reperfusion; Nitric Oxide; Reactive Oxygen Species; Therapeutics.