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Advances on Natural Polyphenols as Anticancer Agents for Skin Cancer

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Advances on Natural Polyphenols as Anticancer Agents for Skin Cancer.
Sajadimajd S1, Bahramsoltani R2, Iranpanah A3, Kumar Patra J4, Das G5, Gouda S6, Rahimi R7, Rezaeiamiri E8, Cao H9, Giampieri F10, Battino M11, Tundis R12, Campos MG13, Farzaei MH14, Xiao J15.
Author information

1
    Faculty of Science, Razi University, Kermanshah, Iran. Electronic address: sajadi.s62@gmail.com.
2
    Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: roodabeh.b.s.88@hotmail.co.uk.
3
    Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: amin.iranpanah75@gmail.com.
4
    Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea. Electronic address: jkpatra@dongguk.edu.
5
    Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi, 10326, Republic of Korea. Electronic address: gdas@dongguk.edu.
6
    Amity Institute of Forestry and Wildlife, Amity University, Noida, Uttar Pradesh, India. Electronic address: sushantogouda@gmail.com.
7
    Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: RojaRahimi@gmail.com.
8
    Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
9
    Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd, Hengqin New Area, Zhuhai, Guangdong, 519031, China. Electronic address: hui_cao0830@yahoo.com.
10
    Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo - Vigo Campus, Vigo, Spain. Electronic address: fgiampie@mta01.univpm.it.
11
    Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo - Vigo Campus, Vigo, Spain; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China. Electronic address: m.a.battino@univpm.it.
12
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036, Rende, CS, Italy. Electronic address: rosa.tundis@unical.it.
13
    Faculty of Pharmacy, University of Coimbra, Heath Sciences Campus, Azinhaga de Santa Comba, Coimbra, Portugal; Coimbra Chemistry Centre (CQC, FCT Unit 313) (FCTUC), University of Coimbra, Rua Larga, Coimbra, Portugal. Electronic address: mgcampos_uc@icloud.com.
14
    Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: mh.farzaei@gmail.com.
15
    Institute of Food Safety and Nutrition, Jinan University, Guangzhou 510632, China. Electronic address: jianboxiao@yahoo.com.

Abstract

Polyphenols are one of most important phytochemicals distributing in herb plants, vegetables and fruits, which known as important anticancer agents. Given the high incidence and mortality of skin cancer, this study aimed to uncover the chemopreventive effects of polyphenols against skin cancer metastasis. Electronic databases including Scopus, PubMed, and Cochrane library were used to compile the literature from 2000 to August 2019. Only in vivo mechanistic studies with English full-texts were chosen for this review. Polyphenols were included in this study if they were administered in purified form; while total extract and fractions were excluded. Among the 8254 primarily selected papers, only a final number of 34 studies were included. The chemopreventive effects of polyphenols as anthocyanins, ellagitanins, EGCG, oleuropeindihydroxy phenyl, punicalagin, quercetin, resveratrol and theaflavin, were mainly examined in treatment of melanoma as the highly metastatic form of this cutaneous cancer. Those properties are mediated by modulation of angiogenesis, apoptosis, inflammation, metastasis, proliferation, pathways such as EGFR/MAPK, mTOR/PI3K/Akt, JAK/STAT, FAK/RTK2, PGE-2/VEGF, PGE-1/ERK/HIIF-1α, and modulation of related signals including NF-κB, P21WAF/CIP1, Bim, Bax, Bcl2, Bclx, Bim, Puma, Noxa, ILs and MMPs. Chemopreventive effects of polyphenols are mediated by several signaling pathways against skin carcinogenesis and metastasis, implying the importance of polyphenols to open up new horizons in development of anti-skin cancer therapeutic strategies.

Copyright © 2019 Elsevier Ltd. All rights reserved.
KEYWORDS:

Polyphenols; drug discovery; metastasis; signaling pathway; skin cancer

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