The effect of plantain syrup on heavy menstrual bleeding: A randomized triple blind clinical trial.
Khodabakhsh M1, Mahmoudinia M2, Mousavi Bazaz M3, Hamedi SS4, Hoseini SS3, Feyzabadi Z1, Shokri S5, Ayati S2.
Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Obstetrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Persian Medicine Department, Birjand University of Medical Sciences, Birjand, Iran.
Given the importance of heavy menstrual bleeding (HMB), we investigated the effect of plantain syrup on HMB. This randomized clinical trial was performed on 68 women with HMB who were referred to the traditional medicine clinics of Mashhad University of Medical Sciences. The intervention group received placebo capsule and plantain syrup, whereas the control group received mefenamic acid capsule and placebo syrup in the first 5 days of menstruation for three menstruation cycles. Patients were asked to complete pictorial blood assessment chart one cycle before the intervention and three intervention cycles. Hemoglobin was measured at the beginning and at the end of the study. The results showed that the bleeding duration and severity diminished in both groups. No significant difference was observed between two groups in severity of bleeding after intervention (Cohen's d = .24), but duration of bleeding in mefenamic acid group was reduced significantly in comparison with plantain group (Cohen's d = .57). Although mean hemoglobin alterations in mefenamic acid group had a significant difference before and after the intervention, there was no significant difference between the two groups in mean hemoglobin alterations postintervention. Plantain syrup could be suggested as a complementary treatment for HMB, but further studies are required.
© 2019 John Wiley & Sons, Ltd.
Plantago major; heavy menstrual bleeding; herbal medicine; hyper menorrhea; menorrhagia