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Improvement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats

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Improvement of fertility parameters with Tribulus Terrestris and Anacyclus Pyrethrum treatment in male rats.
Haghmorad D1,2, Mahmoudi MB3, Haghighi P4, Alidadiani P4, Shahvazian E4, Tavasolian P4, Hosseini M5, Mahmoudi M4.
Author information

1
    Department of Pathology and Laboratory Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
2
    Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
3
    Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4
    Immunology Research Center, BuAli Research Institute, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences.
5
    Neuroscience Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences.

Abstract
OBJECTIVE:

Anacyclus Pyrethrum (AP) and Tribulus Terrestris (TT) have been reported as male infertility treatment in several studies; however, in Iranian traditional medicine these two plants are prescribed simultaneously. In this study, we aimed to determine the effects of AP and TT extracts both separately and simultaneously on the male Wistar rat fertility parameters.
MATERIALS AND METHODS:

32 male Wistar rats were divided into 4 groups: Control, TT, AP, and AT treated groups. Treatment continued for 25 days and rats were weighed daily. Their testes were dissected for histological studies. Sperm analysis including sperm count, viability and motility were performed. Serum was obtained to evaluate testosterone, LH and FSH levels. Histological studies were conducted to study Leydig, and Sertoli cells, spermatogonia and spermatid cell numbers, and to measure seminiferous diameter and epithelium thickness.
RESULTS:

Sperm count increased in all the treatment groups. Sperm viability and motility in AT and AP groups were elevated. TT and AT groups showed signifi cantly increased testosterone level compared to control group (P=004, P=0.000, respectively) and TT, AP and AT treatment groups showed increased LH level (P=0.002, P=0.03 and P=0.000, respectively) compared to control, while only AT group showed increased FSH (p=0.006) compared to control. Histological studies showed signifi cant increase of spermatogonia, Leydig and Sertoli cell numbers and epithelial thickness in AT group compared to other groups. All the treatment groups had higher number of Leydig, spermatogonia and spermatid cells.
CONCLUSION:

TT and AP improved sexual parameters; however, their simultaneous administration had higher improving effects on studied parameters.

Copyright® by the International Brazilian Journal of Urology.
KEYWORDS:

Receptors, FSH; Receptors, LH; Testosterone; Tribulus

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