مشاهده ی مقالات علمی ویژه ی متخصصین

Phytochemical and toxicological evaluation of Tamarix stricta Boiss

011.jpg

Phytochemical and toxicological evaluation of Tamarix stricta Boiss.
Bahramsoltani R1,2, Farzaei MH3,4, Iranpanah A3,5, Hajimahmoudi M6, Pourjabar Z6, Daglia M7, Santarcangelo C7, Rashidi K8, Nabavi SM9, Rahimi R1,2.
Author information

1
    Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences , Tehran , Iran.
2
    PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN) , Tehran , Iran.
3
    Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences , Kermanshah , Iran.
4
    Medical biology Research Center, Kermanshah University of Medical Sciences , Kermanshah , Iran.
5
    Student Research Committee, Kermanshah University of Medical Sciences , Kermanshah , Iran.
6
    Drug and Food Control Department, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran.
7
    Department of Pharmacy, University of Naples Federico II, Naples, Italy.
8
    Research Center of Oils and Fats, Kermanshah University of Medical Sciences , Kermanshah , Iran.
9
    Applied Biotechnology Research Center, Baghyatollah University of Medical Sciences , Tehran , Iran.

Abstract

The genus Tamarix includes several plant species well-known for their medicinal properties since ancient times. Tamarix stricta Boiss is a plant native to Iran which has not been previously investigated regarding its phytochemical and biological properties. This study assessed phytochemical and toxicological aspects of T. stricta. The plant was collected from Kerman province of Iran and after authentication by botanist, it was extracted with 70% ethanol. Total phenolic compounds, total flavonoids, and antioxidant properties were measured using spectrophometric methods. Quercetin content of the extract was measured after complete acid hydrolysis with high-performance liquid chromatography. The phytochemical profile of the extract was provided using liquid chromatography-mass spectrometry method. Acute toxicity study with a single intragastric dose of 5000 mg/kg of the extract and sub-chronic toxicity using 50, 100, and 250 mg/kg of the extract was assessed in Wistar rats. Phytochemical analysis showed that polyphenols constitute the major components of the extract. Also, the extract contained 1.552 ± 0.35 mg/g of quercetin. Biochemical, hematological, and histological evaluations showed no sign of toxicity in animals. Our experiment showed that T. stricta is a rich source of polyphenols and can be a safe medicinal plant. Further pharmacological evaluations are recommended to assess the therapeutic properties of this plant.
KEYWORDS:

Tamarix; flavonoid; halophyte; phytochemical; polyphenol; tamarisk

پست های هم ریشه:

اولین نفری باشید که نظر ارسال می کنید.