مشاهده ی مقالات علمی ویژه ی متخصصین

Promising pain-relieving activity of an ancient Persian remedy

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Abstract

BACKGROUND AND OBJECTIVES:

Chronic low back pain (CLBP) is one the frequent musculoskeletal issues among adults mostly without a specific etiology. In this study, we investigated a traditional Persian remedy for back pain which is based on topical application of a mixture of sesame oil (SO) and white lily (LSM).

 

MATERIALS AND METHODS:

The chemical profile, phenol content, and antioxidant activity of the herbal samples were determined using GC-MS, total phenol content (TPC) assay, and DPPH assay, respectively. Clinical efficacy of the herbal samples by a double-blind placebo was examined.

 

RESULTS:

TPC of SO and LSM was 45 ± 5.7 and 68.3 ± 11.2 mg GAE/g oil mixture, respectively. The SO could inhibit 59.7% of free radicals, whereas LSM showed a radical inhibition rate of 74.7% in DPPH assay. LSM could reduce the pain feeling and obtained the lowest pain scores (Oswestry disability index and numeric rating scale) in weeks 4 and 8 of therapy in comparison to other treatment groups (diclofenac gel and SO) and placebo control (Vaseline).

 

CONCLUSIONS:

The results implicate the LSM as a novel therapeutic alternative for the therapy of the CLBP.

 

KEYWORDS:

Chronic low back pain; Lilium candidum; sesame oil; white lily

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